Reacción #2367781

Ecuación de reacción

2-hydroxy-3,5-diiodobenzoic acid

dimethyl sulfate

acetone

→

solid

methyl 3,5-diiodo-2-methoxybenzoate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturaat reflux for 16 h
3. 3
   Temperaturacooled
4. 4
   Concentraciónconcentrated
5. 5
   workup.DISSOLUTIONThe residue was dissolved in EtOAc
6. 6
   Lavadowashed with water, brine
7. 7
   Secadodried (Na2SO4)
8. 8
   Filtraciónfiltered
9. 9
   Concentraciónconcentrated

Procedimiento

A mixture of 2-hydroxy-3,5-diiodobenzoic acid (3.9 g, 10.0 mmol) potassium carbonate (4.15 g, 30.0 mmol) and dimethyl sulfate (2.77 g, 22.0 mmol) in acetone (33 ml) was heated at reflux for 16 h, cooled and concentrated. The residue was dissolved in EtOAc and washed with water, brine, dried (Na2SO4), filtered and concentrated to give an off-white solid (4.2 g, quantitative yield).

Fuente