Reacción #2358573

Ecuación de reacción

Diphenylmethyl bromide

morpholine

triethylamine

→

title compound

Rendimiento 14.0%

4-Benzhydrylmorpholine

Rendimiento 14.0%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónthe reaction mixture was concentrated in vacuo
2. 2
   Otrothe resulting crude mixture was purified by column chromatography (10% ethyl acetate/hexanes)

Procedimiento

Diphenylmethyl bromide (211 mg, 0.877 mmol) was added to a solution of morpholine (23.9 μL, 0.274 mmol), triethylamine (130 μL, 0.932 mmol) and chloroform (1.4 mL) and was allowed to stir at room temperature. After 48 hr, the reaction mixture was concentrated in vacuo and the resulting crude mixture was purified by column chromatography (10% ethyl acetate/hexanes) to provide the title compound in 14% yield.

Fuente