Reacción #2358560

Ecuación de reacción

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridin-9(10H)-one

compound 11-4

Lawesson's reagent

→

title compound

Rendimiento 86.8%

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione

Rendimiento 86.8%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 4 hrs
2. 2
   OtroToluene was removed by evaporation
3. 3
   workup.ADDITIONTo the residue methanol (20 mL) was added
4. 4
   Filtraciónthe product was collected by filtration
5. 5
   Otrodried

Procedimiento

A mixture of compound 11-4 (560 mg, 1 mmole), anhydrous toluene (10 mL) and Lawesson's reagent (820 mg, 2 mmole) was refluxed for 4 hrs. Toluene was removed by evaporation. To the residue methanol (20 mL) was added, stirred for few minutes at room temperature and the product was collected by filtration and dried to give 500 mg of the title compound. MS 576 (MH+).

Fuente