Reacción #2358525

Ecuación de reacción

tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate

HCl

NaOH

→

title compound

Rendimiento 78.6%

2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethanamine

Rendimiento 78.6%

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate (2×100 ml)
2. 2
   LavadoThe combined organic phase was washed with brine (75 ml)
3. 3
   Secadodried (Na2SO4)
4. 4
   Otroevaporated

Procedimiento

A mixture of tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate (1.4 g, 4.2 mmol) in EtOH (18 ml) was added HCl (1.25 M in EtOH, 6 ml). The mixture was stirred at ambient temperature for 20 h. The aqueous phase was made basic by addition of aqueous NaOH (1 M, 50 ml) and extracted with ethyl acetate (2×100 ml). The combined organic phase was washed with brine (75 ml), dried (Na2SO4) and evaporated to yield the title compound (0.77 g, 77%). MS m/z (relative intensity, 70 eV 298 (M+, 18), 296 (M+, 18), 109 (bp), 107 (99), 82 (15).

Fuente