Reacción #2355138

Ecuación de reacción

(2-chlorophenyl)(4-chlorophenyl)methanol

thionyl chloride

→

(2-chlorophenyl)(4-chlorophenyl)methyl chloride

Rendimiento 102.3%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONUpon completion of the addition the reaction mixture
2. 2
   FiltraciónAfter this time the reaction mixture was filtered
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

A stirred solution of 9.0 grams (0.036 mole) of (2-chlorophenyl)(4-chlorophenyl)methanol in 90 mL of chloroform was cooled to 0° C., and 5.3 mL (0.072 mole) of thionyl chloride was added. Upon completion of the addition the reaction mixture was allowed to warm to ambient temperature, where it stirred for about 18 hours. After this time the reaction mixture was filtered and concentrated under reduced pressure. The filtrate was taken up in hexane and subjected to column chromatography on silica gel with hexane as eluant. The product-containing fractions were combined and concentrated under reduced pressure, yielding 10.0 grams of (2-chlorophenyl)(4-chlorophenyl)methyl chloride. The NMR spectrum was consistent with the proposed structure.

Fuente