Reacción #2345356

Ecuación de reacción

fluorobutyl bromide

magnesium

4'-(4-chloro-4-silacyclohexyl)-4-trifluoromethoxybiphenyl

→

4'-(trans-4-(4-fluorobutyl)-4-silacyclohexyl)-4-trifluoromethoxybiphenyl

Rendimiento 71.0%

Disolventes

THF

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto obtain a Grignard's reagent

Procedimiento

3.1 g (20 mmol) of fluorobutyl bromide was dripped into a mixture of 0.5 g of magnesium (21 mmol) and 50 ml of THF to obtain a Grignard's reagent. This solution was then dripped into a 50 ml THF solution of 7.4 g (20 mmol) of 4'-(4-chloro-4-silacyclohexyl)-4-trifluoromethoxybiphenyl to obtain 4'-(trans-4-(4-fluorobutyl)-4-silacyclohexyl)-4-trifluoromethoxybiphenyl. The silacyclohexane rings of this product were a mixture of trans isomers and cis isomers. They were separated by means of chromatography to obtain 5.8 g of the trans isomers (yield 71%).

Fuente