Reacción #2345

Ecuación de reacción

compound

Methyl 2-t-butoxycarbonylamino-4-[4-[4-(4-pyridyl)-piperazin-1-yl]phenoxy]butyrat

→

title compound

Rendimiento 74.1%

Methyl 2-amino-4-[4-[4-(4-pyridyl) piperazin-1-yl]-phenoxy]butyrate

Rendimiento 74.1%

Disolventes

TFA

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solution was evaporated
2. 2
   workup.DISSOLUTIONthe residue dissolved in water (15 ml)
3. 3
   ExtracciónThe mixture was extracted three times with dichloromethane
4. 4
   OtroEvaporation of the combined extracts

Procedimiento

The compound of Example 140 (0.96 g) in TFA (10 ml) was kept at room temperature for 2 hours. The solution was evaporated and the residue dissolved in water (15 ml) and the solution basified with sodium carbonate. The mixture was extracted three times with dichloromethane. Evaporation of the combined extracts gave the title compound (0.56 g); m.p. 125°-127° C.; NMR(d6DMSO) δ 8.2(2H,d), 6.92(6H,m), 4.0(2H,m), 3.64(3H,s), 3.46(4H,t), 3.15(4H,t), 2.04(2H,m), 1.84(1H, m); m/e 371(M+H)+. Calculated for C20H26N4 O3. 0.75 H2O: C, 62.5; H, 7.17; N, 14.6. Found: C, 62.8; H, 6.8; N, 14.3%.

Fuente