Reacción #2336533

Ecuación de reacción

2-Methylthiophenol

potassium carbonate

DMF

→

title compound

Rendimiento 42.0%

3,6-Bis(2′-methylphenylthio) phthalonitrile

Rendimiento 42.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was isolated
2. 2
   Otroto give a yellow oil
3. 3
   OtroThe material was purified by flash column chromatography (eluting 10% ethyl acetate:isohexane)

Procedimiento

2-Methylthiophenol (10.60 g, 85.5 mmol), potassium carbonate (11.82 g, 82.0 mmol) and ditosylated dicyanohydroquinone (20.00 g, 42.7 mmol) in DMF (75 mL) were reacted as described above. The mixture was isolated as described above to give a yellow oil. The material was purified by flash column chromatography (eluting 10% ethyl acetate:isohexane) to give the title compound as a yellow solid (8.85 g, 23.8 mmol, 42%). [Found: C, 70.7%; H, 4.6%; N, 7.5%; S, 17.2%; C22H16N2S2 requires C, 70.9%; H, 4.3%; N, 7.5%; S, 17.2%]; MS (EI+) 372 (M+, 100%), 357 (M-CH3, 8), 339 (20).

Fuente