Reacción #2336529

Ecuación de reacción

4-(4-trifluoromethylphenoxy) aniline

3-benzyloxy-6-bromo-4-methoxypyridin-2-carbonylchloride

6-BROMO-3-BENZYLOXY-4-METHOXYPYRIDINE-2-CARBONYL CHLORIDE

triethylamine

hydrogen

HCl

→

title compound

N-(2-(4-CHLOROPHENYL)ETHYL)-3-HYDROXYPYRIDINE-2-CARBOXAMIDE

Disolventes

CH2Cl2

CH2Cl2

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic layer was separated
2. 2
   Extracciónthe aqueous layer extracted with CH2Cl2 (2×10 mL)
3. 3
   Secadodried (MgSO4)
4. 4
   Concentraciónconcentrated
5. 5
   Otroto give a gummy solid
6. 6
   Otrofor 30 minutes
7. 7
   FiltraciónThe mixture was filtered
8. 8
   Lavadowashed with 0.1N HCl (20 mL)
9. 9
   Secadodried (MgSO4)
10. 10
    Concentraciónconcentrated

Procedimiento

To a stirred solution of 4-(4-trifluoromethylphenoxy) aniline (0.20 g, 0.8 mmol) and DMAP (0.10 g, 0.085 mmol) in CH2Cl2 (10 mL) was added all at once a solution of 3-benzyloxy-6-bromo-4-methoxypyridin-2-carbonylchloride (3) (0.29 g, 0.8 mmol) in CH2Cl2 (5 mL). The resulting mixture was stirred overnight at room temperature then poured into 2N HCl (10 mL). The organic layer was separated and the aqueous layer extracted with CH2Cl2 (2×10 mL). The organic layers were combined, dried (MgSO4) and concentrated to give a gummy solid. This solid was taken up in EtOAc (20 mL), and triethylamine (0.80 g, 0.8 mmol) and 5% Pd on carbon (0.10 g) were added. The resulting mixture was subjected to a hydrogen atmosphere (initial pressure=50 psi) on a Parr shaker for 30 minutes. The mixture was filtered, washed with 0.1N HCl (20 mL), dried (MgSO4) and concentrated to give the title compound as an off-white solid (0.14 g), m.p.=122-129° C. COUPLING PROCEDURE C: PREPARATION OF N-(4-CYCLOHEXYLPHENYL)-3-HYDROXYPYRIDINE-2-CARBOXAMIDE.

Fuente