Reacción #2336521

Ecuación de reacción

Sodium acetate

7-furyl-3-methyl-4-chromanone

hydroxylamine hydrochloride

→

7-furyl-3-methyl-4-chromanone oxime

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction was quenched with H2O
2. 2
   Extracciónextracted with ether (2×25 mL)
3. 3
   SecadoThe combined organic layers were dried over MgSO4
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated

Procedimiento

Sodium acetate (395 mg, 4.82 mmol) was added portionwise to a solution of 7-furyl-3-methyl-4-chromanone (60) (500 mg, 2.19 mmol) and hydroxylamine hydrochloride (167 mg, 2.41 mmol) in methanol (5 mL), and stirred overnight at room temperature. The reaction was quenched with H2O and extracted with ether (2×25 mL). The combined organic layers were dried over MgSO4, filtered and concentrated to give 7-furyl-3-methyl-4-chromanone oxime (61) as a white solid, m.p. 175-177° C.

Fuente