Reacción #2336518

Ecuación de reacción

Ethyl 4-hydroxypyrimidine-5-carboxylate

LiOH.H2O

→

title compound 19

4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID

Disolventes

THF

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was quenched with conc. HCl (1 mL)
2. 2
   Extracciónextracted with EtOAc (2×20 mL)
3. 3
   ExtracciónThe combined organic extract
4. 4
   Secadowas dried (MgSO4)
5. 5
   Concentraciónconcentrated

Procedimiento

Ethyl 4-hydroxypyrimidine-5-carboxylate can be prepared following the procedure of M. Pesson et al., Eur. J. Med. Chem.—Chim. Ther. 1974, 9, 585. A solution of this ester (500 mg, 3 mmol) in THF (10 mL) and MeOH (5 mL) was treated with LiOH.H2O (373 mg, 8.9 mmol) and stirred overnight. The mixture was quenched with conc. HCl (1 mL) and extracted with EtOAc (2×20 mL). The combined organic extract was dried (MgSO4) and concentrated to give 260 mg of the title compound 19 as an orange solid, m.p. 220° C. (dec). 4-HYDROXY-2-METHYLPYRIMIDINE-5-CARBOXYLIC ACID (20).

Fuente