Reacción #2329046

Ecuación de reacción

benzoic acid (4-chloro-2H-phthalazin-1-ylidene)-hydrazide

triethylamine hydrochloride

water

→

title compound

6-Chloro-3-(3-phenoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine

Disolventes

ethylene glycol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture is cooled to ambient temperature
2. 2
   ExtracciónThe product is extracted with dichloromethane
3. 3
   Secadothe organic layer is dried with sodium sulphate
4. 4
   Concentraciónconcentrated under reduced pressure
5. 5
   OtroThe residue is recrystallized from N,N-dimethylformamide

Procedimiento

2.5 g benzoic acid (4-chloro-2H-phthalazin-1-ylidene)-hydrazide and 1 g triethylamine hydrochloride are suspended in 60 ml ethylene glycol and stirred at 130° C. for 3 h. The reaction mixture is cooled to ambient temperature and added to 600 ml water. The product is extracted with dichloromethane, the organic layer is dried with sodium sulphate and concentrated under reduced pressure. The residue is recrystallized from N,N-dimethylformamide to give the title compound.

Fuente