Reacción #2329042
ord-669213711e004f6493d51356168b95c5
Ecuación de reacción
bisbenzimidazole
N-TBDMS-2,3-dibromomaleimide
TBAF
→
N-benzyl-2,3-dibromomaleimide
bisbenzimidazole
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Tratamiento posterior
- 1Otroto afford 3
Procedimiento
As depicted in Scheme I, bisbenzimidazolomaleimide (3) was synthesized in an economical fashion from readily available precursors in two steps by condensing deprotonated bisbenzimidazole (4) with N-TBDMS-2,3-dibromomaleimide (6a) followed by deprotection with TBAF to afford 3. Lactam 4 was obtained by condensing deprotonated bisbenzimidazole 5 with N-benzyl-2,3-dibromomaleimide 7, yielding 9, followed by a reduction and deprotection sequence, as shown in Scheme 1.