Reacción #2329033

Ecuación de reacción

CH2Cl2

methyl-4-hydroxybenzoate

K2CO3

bromododecane

→

title compound

Rendimiento 95.0%

Methyl 4-dodecyloxybenzoate

Rendimiento 95.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroReaction
2. 2
   Temperaturawas cooled to room temperature
3. 3
   Otroprecipitated into cold water
4. 4
   FiltraciónThe precipitate was collected by suction filtration
5. 5
   Otropurified by re-crystallization from acetone

Procedimiento

To a thoroughly degassed suspension of K2CO3 (127 g, 921 mmol) in DMF (600 mL) was added methyl-4-hydroxybenzoate (70 g, 461 mmol) and the mixture heated to 70° C. after which was added bromododecane (126 g, 507 mmol) and the reaction allowed to stir at 70° C. under argon for 3 hours, after which TLC (CH2Cl2) showed completion. Reaction was cooled to room temperature and precipitated into cold water. The precipitate was collected by suction filtration and purified by re-crystallization from acetone to give the title compound (140 g, 95%).

Fuente