Reacción #2329031

Ecuación de reacción

water

cytosine

diphenylacetyl chloride

→

N4-(Diphenyl acetyl)cytosine

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added in portions
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature overnight
3. 3
   Otrothe end of the reaction
4. 4
   Otrothe solvent was evaporated under reduced pressure
5. 5
   workup.ADDITION100 ml of water were added to the residue
6. 6
   workup.STIRRINGthe mixture was stirred vigorously for 30 minutes
7. 7
   Filtraciónfiltered
8. 8
   LavadoThe white precipitate was washed with 100 ml of ether
9. 9
   Otrodried

Procedimiento

To stirred suspension of (3 gr, 27 mmol) of cytosine (C) in 30 ml of dry pyridine at room temperature (6.85 g, 29.7 mmol) of diphenylacetyl chloride were added in portions. The reaction mixture was stirred at room temperature overnight. TLC indicated the end of the reaction. 2 ml of water was added and the solvent was evaporated under reduced pressure. 100 ml of water were added to the residue and the mixture was stirred vigorously for 30 minutes. The desired product (11) was precipitate and filtered. The white precipitate was washed with 100 ml of ether and dried.

Fuente