Reacción #2329004

Ecuación de reacción

4-{[(6-methoxypyridin-3-yl)methylene]amino}benzene-1,3-diol

DDQ

→

title compound

2-(6-Methoxypyridin-3-yl)-1,3-benzoxazol-6-ol

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONSiO2 was added
2. 2
   Otrothe solvents were removed under reduced pressure
3. 3
   OtroThe crude product was purified by flash column chromatography

Procedimiento

4-{[(6-methoxypyridin-3-yl)methylene]amino}benzene-1,3-diol was dissolved in CH2Cl2 (30 mL) and DDQ was added. The reaction mixture was stirred over night at r.t., SiO2 was added and the solvents were removed under reduced pressure. The crude product was purified by flash column chromatography to give the title compound (189.1 mg). 1H NMR δ ppm 9.88 (s, 1H) 8.90 (dd, 1H) 8.35 (dd, 1H) 7.56 (d, 1H) 7.09 (d, 1H) 6.85 (dd, 1H) 3.95 (s, 3H); MS m/z 243 (M+H).

Fuente