Reacción #2329000

ord-a16b444fab7a4373880947635b28942f

Ecuación de reacción

COc1ccc2nc(-c3ccc(N(CCF)C(=O)OC(C)(C)C)nc3)oc2c1
tert-butyl (2-fluoroethyl)[5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-yl]carbamate
COc1ccc2nc(-c3cnc(NC(=O)OC(C)(C)C)nc3)oc2c1
tert-butyl [5-(6-methoxy-1,3-benzoxazol-2-yl)pyrimidin-2-yl]carbamate
COc1ccc2nc(-c3cnc(N(CCF)C(=O)OC(C)(C)C)nc3)oc2c1
title intermediate
COc1ccc2nc(-c3cnc(N(CCF)C(=O)OC(C)(C)C)nc3)oc2c1
tert-Butyl (2-fluoroethyl)[5-(6-methoxy-1,3-benzoxazol-2-yl)pyrimidin-2-yl]carbamate

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroto give 128 mg

Procedimiento

The title intermediate was synthesized from tert-butyl [5-(6-methoxy-1,3-benzoxazol-2-yl)pyrimidin-2-yl]carbamate according to the procedure described for tert-butyl (2-fluoroethyl)[5-(6-methoxy-1,3-benzoxazol-2-yl)pyridin-2-yl]carbamate to give 128 mg. 1H NMR 400 MHz, Chloroform-d) δ ppm 9.33 (s, 2H) 7.66 (d, 1H) 7.14 (d, 1H) 7.00 (dd, 1H) 4.79 (t, 1H) 4.67 (t, 1H) 4.42 (t, 1H) 4.37 (t, 1H) 3.90 (s, 3 H) 1.57 (s, 9H) MS m/z 389 (M+H).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07670591B2uspto-grants-2010_03