Reacción #2314286

Ecuación de reacción

HCl

phenol

4-[2-(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)ethyl]phenol

tosylate

cesium carbonate

→

4-[2-(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)ethyl]-1-(4-pentyl-3-cyclohexenyl)methoxybenzene

Disolventes

dimethylforrnamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroTo a round-bottom flask equipped with a stirbar
2. 2
   Extracciónextracted with 1:1 hexanes
3. 3
   LavadoThe combined organic layers are washed with brine
4. 4
   Secadodried over potassium carbonate
5. 5
   Concentraciónthe solution is concentrated in vacuo
6. 6
   FiltraciónFiltration through silica gel using 10% ethyl acetate in hexanes
7. 7
   Otrogives the pure product

Procedimiento

To a round-bottom flask equipped with a stirbar is added phenol 2G (R=4-Methyl-3-pentenyl) (5 g), tosylate 1H (R=n-pentyl) (5.95 g), cesium carbonate (7.45 g), and anhydrous dimethylforrnamide (50 mL). The reaction mixture is stirred overnight. It is then poured into 50 mL dilute HCl, and extracted with 1:1 hexanes:ethyl acetate. The combined organic layers are washed with brine and dried over potassium carbonate, and the solution is concentrated in vacuo. Filtration through silica gel using 10% ethyl acetate in hexanes gives the pure product.

Fuente