Reacción #2314281

Ecuación de reacción

hydrochloric acid

sodium hydroxide

nitrile

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

water

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

Disolventes

hydrogen peroxide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux overnight
2. 2
   ExtracciónThe acid product is extracted with ethyl acetate
3. 3
   Lavadothe combined organic layers are washed with brine
4. 4
   Secadodried over magnesium sulfate
5. 5
   ConcentraciónThe solution is concentrated in vacuo

Procedimiento

To a solution of sodium hydroxide (10.5 g) in water (150 mL) and 30% hydrogen peroxide (50 mL) is added the nitrile 2A (R=4-Methyl-3-pentenyl) (10 g). The reaction mixture is stirred at reflux overnight. The reaction is then cooled to room temperature, and poured into a mixture of ice (30 g) and hydrochloric acid (22 mL). The acid product is extracted with ethyl acetate, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

Fuente