Reacción #2314279

Ecuación de reacción

bromopentane

→

2-Pentyl-1,3-butadiene

Disolventes

ammonium chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturagradually warming to room temperature
2. 2
   workup.STIRRINGThe reaction mixture is stirred for 10 minutes, during which time the aqueous layer
3. 3
   ExtracciónThe reaction mixture is then extracted with hexanes
4. 4
   Secadothe combined organic layers are dried over magnesium sulfate
5. 5
   OtroThe solvent is carefully removed by rotary evaporation
6. 6
   Otroto give 17 g of a colorless, malodorous liquid

Procedimiento

To a flask containing cuprous bromide (1.0 g) is added bromopentane (23 g) and tetrahydrofaran (154 mL). The solution is cooled to 0° C., and the Grignard reagent 1B is added. The reaction is stirred overnight, gradually warming to room temperature. To the solution is then added 30 mL saturated ammonium chloride. The reaction mixture is stirred for 10 minutes, during which time the aqueous layer turns blue. The reaction mixture is then extracted with hexanes, and the combined organic layers are dried over magnesium sulfate. The solvent is carefully removed by rotary evaporation to give 17 g of a colorless, malodorous liquid.

Fuente