Reacción #2314018

Ecuación de reacción

4-chloropyrido-[2,3-d]pyrimidine

2-[4-(t-butyl)phenyl]ethanol

HCl

→

4-[2-[4-(t-butyl)phenyl]ethoxy]pyrido[2,3-d]pyrimidine

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was then cooled
2. 2
   Otroa yellow solid was collected
3. 3
   LavadoThis was washed with hexane
4. 4
   Otropartitioned between 1N NaOH and CH2Cl2
5. 5
   SecadoThe CH2Cl2 layer was dried over MgSO4
6. 6
   Otrothe solvent was removed under vacuum
7. 7
   Otroto leave a yellow solid, which
8. 8
   Otrowas recrystallized from hexane

Procedimiento

A mixture consisting of 1.86 g (0.011 mole) of 4-chloropyrido-[2,3-d]pyrimidine, 2.0 g (0.011 mole) of 2-[4-(t-butyl)phenyl]ethanol, and 40 mL of toluene containing a little HCl gas was stirred at room temperature. The mixture was then cooled, and a yellow solid was collected. This was washed with hexane, then partitioned between 1N NaOH and CH2Cl2. The CH2Cl2 layer was dried over MgSO4, then the solvent was removed under vacuum to leave a yellow solid, which was recrystallized from hexane. Yield 2.5 g. M.P. 77°-79° C.

Fuente