Reacción #2298647

Ecuación de reacción

4-[2-[4-methyl-2-propyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]benzaldehyde

thiazolidine-2,4-dione

benzoic acid

piperidine

→

title compound

Rendimiento 125.7%

5-[4-[2-[4-Methyl-2-propyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]phenyl methylene]thiazolidine-2,4-dione

Rendimiento 125.7%

Disolventes

water

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe resultant crystalline compound was filtered
2. 2
   Lavadowashed with water
3. 3
   Otrodried

Procedimiento

A mixture of 4-[2-[4-methyl-2-propyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]benzaldehyde (10 g, 24.5 mmol) (obtained from preparation 1), thiazolidine-2,4-dione (3.5 g, 30 mmol), benzoic acid (388 mg, 3.18 mmol) and piperidine (352 μl, 303 mg, 3.68 mmol) in toluene (50 ml) was refluxed for 1 h with continuous removal of water. The reaction was cooled to room temperature and the resultant crystalline compound was filtered and washed with water and dried to afford the title compound (12.3 g, 99%), mp 240-242° C.

Fuente