Reacción #2298639

ord-aef83587081041b89896d1ff589ac3f1

Ecuación de reacción

Cn1c(CCl)nc(=O)c2ccccc21
2-chloromethyl-1-methyl-4-oxo-1,4-dihydroquinazoline
O=Cc1ccc(O)cc1
4hydroxybenzaldehyde
O=C([O-])[O-].[K+].[K+]
K2CO3
Cn1c(COc2ccc(C=O)cc2)nc(=O)c2ccccc21
title compound
Rendimiento 65.0%
Cn1c(COc2ccc(C=O)cc2)nc(=O)c2ccccc21
4-[[1-methyl-4-oxo-1,4-dihydro-2-quinazolinyl]methoxy]benzaldehyde
Rendimiento 65.0%

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otrothat described in preparation 13

Procedimiento

The title compound (3.64 mg, 65%) was prepared from 2-chloromethyl-1-methyl-4-oxo-1,4-dihydroquinazoline (416 mg, 2.0 mmol) and 4hydroxybenzaldehyde (244 mg, 2.0 mmol) in the presence of K2CO3 (276 mg, 2.0 mmol) as base by a similar procedure to that described in preparation 13.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: USRE039266E1uspto-grants-2006_09