Reacción #2298637

Ecuación de reacción

4-hydroxybenzaldehyde

K2CO3

2-chloromethyl-3-methyl-4-oxo-3,4-dihydroquinazoline

→

title compound

Rendimiento 72.0%

4-[[3-Methyl-4-oxo-3,4-dihydro-2-quinazolinyl]methoxy]benzaldehyde

Rendimiento 72.0%

Disolventes

DMF

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGstirred further for 90 minutes at the same temperature
2. 2
   Lavadowashed with aqueous Na2CO3 solution (3×50 ml)
3. 3
   Secadowith brine, dried over anhydrous Na2SO4
4. 4
   Concentraciónconcentrated

Procedimiento

A mixture of 4-hydroxybenzaldehyde (3.21 g, 26.3 mmol and K2CO3 (3.64 g, 26.3 mmol) in dry DMF (50 ml) was stirred for 15 min at 30° C. To the above stirred mixture a solution of 2-chloromethyl-3-methyl-4-oxo-3,4-dihydroquinazoline (5.0 g, 24.0 mmol) was added and stirred further for 90 minutes at the same temperature. The reaction mixture was diluted with EtOAc (200 ml), washed with aqueous Na2CO3 solution (3×50 ml) and then with brine, dried over anhydrous Na2SO4 and concentrated to yield the title compound (5.08 g, 72%).

Fuente