Reacción #2298623

Ecuación de reacción

(7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride

(7-Bromothieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride

3-pyridinecarboxaldehyde

→

3-pyridinecarboxaldehyde(7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazone

Rendimiento 81.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturaat reflux for 4 hours
3. 3
   Filtraciónthe solid product was collected by vacuum filtration

Procedimiento

A suspension of (7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (168, 29 mg, 0.12 mmol) and 3-pyridinecarboxaldehyde (18 mg, 0.17 mmol) in ethanol (2 mL) was heated at reflux for 4 hours. After cooling to room temperature, the solid product was collected by vacuum filtration to yield 3-pyridinecarboxaldehyde(7-bromothieno[3,2-d]pyrimidin-4-yl)hydrazone (32 mg, 81% yield) as a pale yellow solid.

Fuente