Reacción #2298613

Ecuación de reacción

acetic anhydride

methyl 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

→

3-(formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester

Rendimiento 95.0%

Disolventes

Formic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawhile cooling in an ice bath
2. 2
   OtroThe cooling bath was removed
3. 3
   workup.ADDITIONThe reaction mixture was diluted with water (100 mL)
4. 4
   Filtraciónthe solid product collected by vacuum filtration

Procedimiento

Formic acid (53 mL) was added to acetic anhydride (53 mL) while cooling in an ice bath. Solid methyl 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester (1, 18.2 g, 0.11 mol) was added to the cold solution in small portions. The cooling bath was removed and the resulting suspension was stirred at room temperature for 4 hours. The reaction mixture was diluted with water (100 mL) and the solid product collected by vacuum filtration to yield 3-(formylamino)-4-methyl-2-thiophenecarboxylic acid methyl ester (20.2 g, 95% yield) as a white solid.

Fuente