Reacción #2298461

ord-ae7c5f87032f4285b450d0de50691028

Ecuación de reacción

O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
COC(=O)CCc1nc(-c2ccc(C3CCNCC3)cc2)cs1
2-(2-methoxycarbonyl-ethyl)-4-[4-(4-piperidinyl)-phenyl]-thiazole
Br.CCSC(=N)N
S-ethylisothiourea-hydrobromide
→
COC(=O)CCc1nc(-c2ccc(C3CCN(C(=N)N)CC3)cc2)cs1
4-[4-(1-Amidino-4-piperidinyl)-phenyl]-2-(2-methoxycarbonyl-ethyl)-thiazole

Reactantes

O=C([O-])[O-].[Na+].[Na+]
sodium carbonate
COC(=O)CCc1nc(-c2ccc(C3CCNCC3)cc2)cs1
2-(2-methoxycarbonyl-ethyl)-4-[4-(4-piperidinyl)-phenyl]-thiazole
Br.CCSC(=N)N
S-ethylisothiourea-hydrobromide

Reactivos

Ninguno

Disolventes

CN(C)C=O
dimethylformamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared from 2-(2-methoxycarbonyl-ethyl)-4-[4-(4-piperidinyl)-phenyl]-thiazole and S-ethylisothiourea-hydrobromide by heating to 100° C. for 4 hours in dimethylformamide in the presence of sodium carbonate.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05463071uspto-grants-1995_10