Reacción #2295

Ecuación de reacción

4-fluorobenzoyl chloride

ethanol

→

ethyl 4-fluorobenzoate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturais refluxed for 15 minutes

Procedimiento

A mixture containing 35 g of 4-fluorobenzoyl chloride in 50 ml of 100% ethanol is refluxed for 15 minutes. 35 g of the ethyl 4-fluorobenzoate obtained are mixed with 22 g of imidazole and 61 g of potassium carbonate in 35 ml of DMSO. The mixture is heated for 18 hours at 120°-130° C. and 500 ml of iced water are then added. A precipitate forms and the expected product crystallizes from iso ether.

Fuente