Reacción #2292791

Ecuación de reacción

CbzCl

(S)-1-(6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethan-1-amine

triethylamine

→

title compound

Rendimiento 94.7%

Benzyl (S)-(1-(6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethyl)carbamate

Rendimiento 94.7%

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the solvent was removed
2. 2
   Otrothe residue was purified by silica gel column chromatography (PE/EtOAc=10:1)

Procedimiento

To a stirred solution of (S)-1-(6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)ethan-1-amine (1.0 g, 3.93 mmol) in DCM (20 mL) was added triethylamine (796 mg, 7.87 mmol) followed by CbzCl (808 mg, 4.72 mmol) at 0° C. The reaction mixture was stirred at about 0 to 26° C. for 1.5 hours. After the solvent was removed, the residue was purified by silica gel column chromatography (PE/EtOAc=10:1) to give the title compound as a yellow oil (1.44 g, 94.7%).

Fuente