Reacción #2281980

Ecuación de reacción

1-bromo-3-methoxy-5-methyl-benzene

DMF

→

solid

Rendimiento 83.0%

3-Methoxy-5-methyl-benzonitrile

Rendimiento 83.0%

Disolventes

Ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadoby washing with brine
2. 2
   ConcentraciónThe organic layer was concentrated
3. 3
   Otropurified (silica gel, 0-50% EtOAC/hexane)

Procedimiento

In a 100 mL round bottom flask, 1-bromo-3-methoxy-5-methyl-benzene (2.17 g, 10.79 mmol), Zn(CN)2 (1.9 g, 16.19 mmol, 1.5 eq.) and Pd(PPh3)4 (1.24 g, 1.08 mmol, 0.1 eq.) was charged with DMF (20 mL). The reaction mixture was heated at 90° C. under Ar for 7 hours. Ethyl acetate was added, followed by washing with brine. The organic layer was concentrated and purified (silica gel, 0-50% EtOAC/hexane) to give a white solid (1.31 g, 83%). 1H NMR (300 MHz, CDCl3): δ 7.05 (s, 1H), 6.97 (s, 2H), 3.81 (s, 3H), 2.39 (s, 3H).

Fuente