Reacción #2275746

ord-085b74f84cda45768dbf7a15f1a7e4af

Ecuación de reacción

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
Cc1cccn(C2CCC(=O)CC2)c1=O
3-methyl-1-(4-oxo-cyclohexyl)-1H-pyridin-2-one
Cc1cccn(C2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1=O
title compounds
Cc1cccn(C2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1=O
N-({1-[4-(3-Methyl-2-oxo-2H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compounds were prepared as white solids from the reductive amination of 3-methyl-1-(4-oxo-cyclohexyl)-1H-pyridin-2-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08324186B2uspto-grants-2012_12