Reacción #2275744

ord-3842917af61f491d9319f3846c83dfe6

Ecuación de reacción

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
O=C1CCC(n2ccc(=O)cc2)CC1
1-(4-oxo-cyclohexyl)-1H-pyridin-4-one
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3ccc(=O)cc3)CC2)C1
title compounds
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN(C2CCC(n3ccc(=O)cc3)CC2)C1
N-({1-[4-(4-Oxo-4H-pyridin-1-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compounds were prepared as white solids from the reductive amination of 1-(4-oxo-cyclohexyl)-1H-pyridin-4-one (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08324186B2uspto-grants-2012_12