Reacción #2275727

Ecuación de reacción

1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyridin-2-one

HCl

sodium bicarbonate

→

title compound

1-(4-Oxo-cyclohexyl)-1H-pyridin-2-one

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed in vacuo and residue
2. 2
   Otropartitioned between ethyl acetate and water
3. 3
   LavadoThe organic layer was washed with brine
4. 4
   Secadodried over anhydrous Na2SO4
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated

Procedimiento

A solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyridin-2-one (as prepared in the previous step, ˜300 mg, 1.28 mmol)) in acetone (10 mL) was treated with 1N HCl (2 mL) at room temperature for 4 hours. The reaction was worked up with saturated sodium bicarbonate to adjust the pH to neutral. The solvent was removed in vacuo and residue partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered, concentrated to afford the title compound as white solid.

Fuente