Reacción #2275699
ord-062db9925aa24781930210f38604e13f
Ecuación de reacción
{[5-(3-cyano-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}acetic acid methyl ester
trimethylsilyl azide
di-butyl tin oxide
DME
→
({5-[3-(Cyclopropanecarbonyl-amino)-phenyl]-3-hydroxy-pyridine-2-carbonyl}-amino)-acetic acid methyl ester
Reactantes
Reactivos
Ninguno
Condiciones de reacción
Temperatura
140°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
The following heteroaryl substituted phenyl compound can be prepared from {[5-(3-cyano-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}acetic acid methyl ester by treatment with trimethylsilyl azide and di-butyl tin oxide in DME and heating the mixture to 140° C., 150 W, 200 psi in a microwave reactor.