Reacción #2273674

Ecuación de reacción

methyl-2-(N-benzoylamino)methyl-3-oxobutyrate

NEt3

→

title compound

Rendimiento 90.0%

methyl (2S,3R)-2-(N-benzoylamino)methyl-3-hydroxybutyrate

Rendimiento 90.0%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed by evaporation under reduced pressure
2. 2
   Otrothe residue was purified by column chromatography

Procedimiento

In a 100 ml autoclave was put a solution of 2.5 g (10 mmol) of methyl-2-(N-benzoylamino)methyl-3-oxobutyrate and 173 mg (0.102 mmol) of Ru2Cl4((R)-BINAP)2.NEt3 in 17.5 ml of methylene chloride, and the mixture was stirred at 50° C. under a hydrogen pressure of 10000 kPa for 20 hours. The solvent was removed by evaporation under reduced pressure, and the residue was purified by column chromatography to furnish 2.25 g (90%) of the title compound. Optical purity: 98%e.e.

Fuente