Reacción #2272

Ecuación de reacción

acetic acid

2-(4-chlorophenyl)-3-dimethylaminopropenal

sodium methoxide

cyanoacetamide

→

3-cyano-5-(4-chlorophenyl)-2-pyridinone

Disolventes

water

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe resulting suspension was refluxed overnight
2. 2
   OtroDuring this time a yellow solid was formed
3. 3
   FiltraciónThe resulting yellow orange solid was filtered off
4. 4
   Lavadowashed several times with water
5. 5
   Otrodried

Procedimiento

To solution of sodium methoxide (7.52 g) in methanol (130 ml) was added cyanoacetamide (5.84 g) followed by 2-(4-chlorophenyl)-3-dimethylaminopropenal and the resulting suspension was refluxed overnight. During this time a yellow solid was formed. The mixture was cooled to room temperature and glacial acetic acid (50 ml) was added followed by water (100 ml). The resulting yellow orange solid was filtered off, washed several times with water and dried to yield 8.1 g of 3-cyano-5-(4-chlorophenyl)-2-pyridinone.

Fuente