Reacción #2271682

Ecuación de reacción

6-fluoro-3-(4-piperdinyl)-1,2-benzisoxazole

K2CO3

3-chloropropoxybenzene

acetonitrile

→

6-fluoro-3-[1-(3-phenoxypropyl)-4-piperidinyl)-1,2-benzisoxazole

Rendimiento 47.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux under nitrogen for 30 hours
2. 2
   Extracciónthe aqueous mixture was extracted with ethyl acetate
3. 3
   ExtracciónThe ethyl acetate extract
4. 4
   Lavadowas washed with brine
5. 5
   Otrodried with MgS04
6. 6
   Concentraciónconcentrated
7. 7
   Otroto afford 6.2 g of a damp, beige solid
8. 8
   OtroThe compound was recrystallized twice from ethanol

Procedimiento

A mixture of 6-fluoro-3-(4-piperdinyl)-1,2-benzisoxazole (4.0 g, 18.2 mmol). K2CO3 (3.0 g, 21.8 mmol), Kl (100 mg), 3-chloropropoxybenzene (3.4 g, 20.0 mmol), and acetonitrile was stirred at reflux under nitrogen for 30 hours. The reaction was poured into water and the aqueous mixture was extracted with ethyl acetate. The ethyl acetate extract was washed with brine, dried with MgS04 and concentrated to afford 6.2 g of a damp, beige solid. The compound was recrystallized twice from ethanol to yield (47%) of 6-fluoro-3-[1-(3-phenoxypropyl)-4-piperidinyl)-1,2-benzisoxazole as a light beige solid, m.p.=78°-80° C.

Fuente