Reacción #2271678

Ecuación de reacción

6-fluoro-3-(4-piperidinyl)-1H-indazole

K2CO3

1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone

acetonitrile

→

desired product

Rendimiento 80.8%

1-[4-[3-[4-(6-Fluoro-1H-indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]-ethanone

Rendimiento 80.8%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe resulting white solid, which precipitated from solution
2. 2
   Otrowas collected

Procedimiento

A stirred mixture of 6-fluoro-3-(4-piperidinyl)-1H-indazole (3.5 g, 16 mmol). K2CO3 (2.2 g). 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (3.8 g, 16 mmol) and acetonitrile (90 ml) was refluxed for 16 hours. The reaction was poured into water and the resulting white solid, which precipitated from solution, was collected to afford 5.5 g of the desired product. The compound was recrystallized from dimethylformamide (twice) to afford 3.0 g (44%) of 1-[4-[3-[4-(6-fluoro-1H-indazol-3-yl)-1-piperidinyl]propoxy]-methoxyphenyl]ethanone as a white solid, m.p.=202°-204° C.

Fuente