Reacción #2267080

Ecuación de reacción

22

6-Acetylamino-1-hydroxy-3-methyl-1-(4-nitrophenyl)-7-methoxyisochroman

acetic hydrazide

→

desired product 23

Rendimiento 86.5%

2′-Acetylamino-6′-(2-hydroxypropyl)-3′-methoxy-4-nitrobenzophenone acetylhydrazone

Rendimiento 86.5%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting solution was refluxed for 3 hours
2. 2
   OtroThe solvent was removed under reduced pressure
3. 3
   workup.ADDITIONThe residue was treated with NaHCO3
4. 4
   Extracciónextracted with ethyl acetate
5. 5
   LavadoThe combined organic phases were washed with brine
6. 6
   Secadodried over Na2SO4
7. 7
   OtroRemoval of the solvent

Procedimiento

To a solution of 22 (1.7 g) in 25 ml of ethanol was added acetic hydrazide (0.5 g) and 2 drops of concentrated HCl. The resulting solution was refluxed for 3 hours. The solvent was removed under reduced pressure. The residue was treated with NaHCO3, and extracted with ethyl acetate. The combined organic phases were washed with brine, dried over Na2SO4. Removal of the solvent gave the desired product 23 (1.25 g).

Fuente