Reacción #2267070

Ecuación de reacción

4

1-Hydroxy-3-methyl-1-(4-nitrophenyl)-6-methoxyisochroman

acetic hydrazide

→

desired product

Rendimiento 66.3%

6′-(2-Hydroxypropyl)-4′-methoxy-4-nitrobenzophenone acetylhydrazone

Rendimiento 66.3%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting solution was heated
2. 2
   Temperaturato reflux for 3 hours
3. 3
   OtroThe solvent was removed under reduced pressure
4. 4
   workup.ADDITIONThe residue was treated with NaHCO3
5. 5
   Extracciónextracted with ethyl acetate
6. 6
   LavadoThe combined organic phase was washed with brine
7. 7
   Secadodried over Na2SO4
8. 8
   OtroRemoval of the solvent

Procedimiento

To a solution of 4 (1.6 g) in 25 ml of ethanol was added acetic hydrazide (0.4 g) and 2 drops of concentrated HCl. The resulting solution was heated to reflux for 3 hours. The solvent was removed under reduced pressure. The residue was treated with NaHCO3, and extracted with ethyl acetate. The combined organic phase was washed with brine, dried over Na2SO4. Removal of the solvent gave the desired product (1.25 g).

Fuente