Reacción #2267069

Ecuación de reacción

3

3-Methyl-1-(4-nitrophenyl)-6-methoxyisochroman

sodium hydroxide

HCl

→

crude product

1-Hydroxy-3-methyl-1-(4-nitrophenyl)-6-methoxyisochroman

Disolventes

DMSO

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate three times
2. 2
   LavadoThe combined organic phase was washed with water in order
3. 3
   Otroto remove DMF
4. 4
   Secadodried over Na2SO4
5. 5
   OtroRemoval of the solvent

Procedimiento

A solution of 3 (1.3 g) in 4 ml of DMSO and 24 ml of DMF was cooled to 8-12° C. and air was passed through the mixture. To the solution was added 1.2 ml of 50% aqueous sodium hydroxide in one portion and the resulting mixture was stirred for 5 hours. HCl (1 N) was added, and extracted with ethyl acetate three times. The combined organic phase was washed with water in order to remove DMF, dried over Na2SO4. Removal of the solvent afforded syrup crude product (1.6 g), which was used directly for the next step.

Fuente