Reacción #2267067

Ecuación de reacción

3-methoxyphenylacetone

NaBH4

→

desired product 2

Rendimiento 100.0%

1-(3-Methoxyphenyl)-2-propyl alcohol

Rendimiento 100.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónIt was extracted with CHCl3 three times
2. 2
   LavadoThe combined organic phase was washed with brine
3. 3
   Secadodried over Na2SO4
4. 4
   OtroRemoval of the solvent
5. 5
   Otroafforded the crude product
6. 6
   OtroPurification of the crude product

Procedimiento

To a solution of 3-methoxyphenylacetone (1, 1.0 g) in methanol (30 ml) was added NaBH4 (360 mg) in portions in the period of 20 min at 0° C. The resulting solution was stirred at such temperature for another 40 min. No more starting materials were detected from TLC. Ice water was added to the reaction slowly. It was extracted with CHCl3 three times. The combined organic phase was washed with brine, and dried over Na2SO4. Removal of the solvent afforded the crude product. Purification of the crude product by using a silica gel column gave the desired product 2 (1.01 g, 100%).

Fuente