Reacción #2254179

Ecuación de reacción

HCl

5-[1,3]dioxolan-2-yl-3-methyl-thiophene-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

→

5-formyl-3-methyl-thiophene-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Rendimiento 51.2%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroone night at room temperature, the reaction is quenched with water
2. 2
   ExtracciónThe reaction mixture is extracted three times with ethyl acetate
3. 3
   SecadoThe combined organic phases are dried over Na2SO4
4. 4
   Concentraciónconcentrated in vacuo
5. 5
   OtroThe crude product is purified on a semi-preparative HPLC

Procedimiento

HCl (2N, 4 ml) is added to a solution of 5-[1,3]dioxolan-2-yl-3-methyl-thiophene-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide (450 mg) in acetone (10 ml). After 4 hours at 50° C. and one night at room temperature, the reaction is quenched with water. The reaction mixture is extracted three times with ethyl acetate. The combined organic phases are dried over Na2SO4 and concentrated in vacuo. The crude product is purified on a semi-preparative HPLC to yield 5-formyl-3-methyl-thiophene-2-carboxylic acid (2,2,2-trifluoro-ethyl)-amide (196 mg) as a yellowish oil. MS (HPLC/MS): 252 (MH+). Retention time: 2.54 min.

Fuente