Reacción #2254159

Ecuación de reacción

2-(3-chloro-2-pyridyl)-N-[2,4-dichloro-6-hydroxycarbonyl-phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide

acetic anhydride

→

title compound

Rendimiento 57.1%

6,8-dichloro-2-[2-(3-chloro-pyridin-2-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]benzo[d][1,3]oxazin-4-one

Rendimiento 57.1%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe resulting solid was filtered
2. 2
   Lavadowashed with cold methylene chloride

Procedimiento

To a solution of 2-(3-chloro-2-pyridyl)-N-[2,4-dichloro-6-hydroxycarbonyl-phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide (18.4 g, 38.3 mmol) in methylene chloride (130 mL) was added acetic anhydride (39.4 mL, 417 mmol). The reaction was then heated to 55° C. for 2 h and then stirred for a further 16 h at room temperature. The resulting solid was filtered and washed with cold methylene chloride. Trituration with diethyl ether afforded the title compound (10.1 g, 57%).

Fuente