Reacción #2245

Ecuación de reacción

3-(4-pyridinylamino)-1,2-benzisoxazole

methyl bromoacetate

→

title compound

Rendimiento 70.0%

[4-(3-Benzo[d]isoxazolylimino)-1-(4H)-pyridinyl]-acetic acid methyl ester hydrobromide

Rendimiento 70.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturaat reflux for one hour
3. 3
   Filtraciónthe precipitated product was collected by filtration
4. 4
   LavadoThe white solid was washed with diethyl ether
5. 5
   Otrodried under vacuum

Procedimiento

A mixture of 3-(4-pyridinylamino)-1,2-benzisoxazole (0.9 g, 4.3 mmol) and methyl bromoacetate (0.44 mL, 1.1 eq) in acetonitrile (25 mL) was heated at reflux for one hour. The mixture was then allowed to cool to room temperature and the precipitated product was collected by filtration. The white solid was washed with diethyl ether and dried under vacuum to provide the title compound (1.1 g, 70%), mp 235-236° C.

Fuente