Reacción #220958

Ecuación de reacción

(4-Hydroxyphenethyl) alcohol

hydrobromic acid

→

product

Rendimiento 92.0%

4-(2-Bromoethyl)phenol

Rendimiento 92.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter being cooled
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe extracts were washed with water
4. 4
   Otrodried
5. 5
   Concentraciónconcentrated in vacuo
6. 6
   Otroto give a raw product
7. 7
   OtroPurification by flash chromatography (heptane/ethyl acetate 9:1)

Procedimiento

(4-Hydroxyphenethyl) alcohol (1.50 g, 0.01086 mol) and 48 wt. % hydrobromic acid (10 ml) were heated at 100° C. for 1.5 h. After being cooled, the reaction mixture was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and concentrated in vacuo to give a raw product. Purification by flash chromatography (heptane/ethyl acetate 9:1) gave a pure product (2.01 g, 92%). 1H NMR (400 MHz, DMSO-d6): 2.99 (2H, t, 3J=7.4 Hz), 3.63 (2H, t, 3J=7.4 Hz), 6.68 (2H, d, 3J=8.5 Hz), 7.05 (2H, d, 3J=8.3 Hz), 9.24 (1H, s, —OH).

Fuente