Reacción #220953

Ecuación de reacción

4-(Benzyloxy)phenol

2-(dimethylamino)ethyl chloride hydrochloride

sodium hydride

water

→

[2-(4-Benzyloxyphenoxy)ethyl]dimethylamine

Disolventes

dimethylformamide

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe resultant mixture was extracted with toluene
2. 2
   LavadoThe combined extracts were washed with 2.5 M NaOH and water
3. 3
   Secadodried over Na2SO4
4. 4
   OtroToluene was evaporated

Procedimiento

4-(Benzyloxy)phenol (2.89 g, 0.01443 mol) in dimethylformamide (15 ml) and 2-(dimethylamino)ethyl chloride hydrochloride (2.32 g, 0.01611 mol) were added simultaneously in small portions to a 55-65% sodium hydride dispersion in mineral oil (0.033 mol) in dimethylformamide (5 ml) at 0° C. Then the mixture was allowed to warm to 90° C., and stirring was continued for 1.5 h. The cooled mixture was poured into water. The resultant mixture was extracted with toluene. The combined extracts were washed with 2.5 M NaOH and water and dried over Na2SO4. Toluene was evaporated and the residual product was used as such in the next step.

Fuente