Reacción #220904

ord-7cf065c723a84cca81ba7b5a9a6b68ca

Ecuación de reacción

COc1ccc(C2C(CCC(O)c3ccc(O)cc3)C(=O)N2c2ccc(F)cc2)cc1
1-(4-Fluorophenyl)-3-[3-hydroxy-3-(4-hydroxyphenyl)-propyl]-4-(4-methoxyphenyl)-azetidin-2-one
BrCc1ccc(CBr)cc1
1,4-bisbromomethylbenzene
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
COc1ccc(C2C(CCC(O)c3ccc(OCc4ccc(CBr)cc4)cc3)C(=O)N2c2ccc(F)cc2)cc1
solid ( 29 )
COc1ccc(C2C(CCC(O)c3ccc(OCc4ccc(CBr)cc4)cc3)C(=O)N2c2ccc(F)cc2)cc1
3-{3-[4-(4-Bromomethylbenzyloxy)-phenyl]-3-hydroxypropyl}-1-(4-fluorophenyl)-4-(4-methoxyphenyl)-azetidin-2-one

Reactantes

COc1ccc(C2C(CCC(O)c3ccc(O)cc3)C(=O)N2c2ccc(F)cc2)cc1
1-(4-Fluorophenyl)-3-[3-hydroxy-3-(4-hydroxyphenyl)-propyl]-4-(4-methoxyphenyl)-azetidin-2-one
BrCc1ccc(CBr)cc1
1,4-bisbromomethylbenzene
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

1-(4-Fluorophenyl)-3-[3-hydroxy-3-(4-hydroxyphenyl)-propyl]-4-(4-methoxyphenyl)-azetidin-2-one was reacted with 1,4-bisbromomethylbenzene and potassium carbonate analogously to Example IV, giving a colorless solid (29) of molecular weight 604.52 (C33H31BrFNO4); MS (ESI): 605.2 (MH+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07390790B2uspto-grants-2008_06