Reacción #219768

Ecuación de reacción

5-fluoro-1-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-one

2-oxiranylmethoxy-benzoic acid tert-butyl ester

→

solid

Rendimiento 99.0%

(S)-2-{3-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-1-yl)piperidin-1-yl]-2-hydroxy-propoxy}-benzoic acid tert-butyl ester

Rendimiento 99.0%

Disolventes

isopropanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroafter which the solvent was removed in vacuo
2. 2
   OtroThe residue was purified by gradient flash chromatography on silica gel (CH2Cl2 to EtOH)

Procedimiento

A solution of 5-fluoro-1-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-one (235 mg, 0.5 mmol) and 2-oxiranylmethoxy-benzoic acid tert-butyl ester (250 mg, 1.0 mmol) in isopropanol (iPrOH) (10 mL) was stirred at 70° C. for 14 h, after which the solvent was removed in vacuo. The residue was purified by gradient flash chromatography on silica gel (CH2Cl2 to EtOH), yielding an off-white solid (240 mg, 99%).

Fuente