Reacción #219703

Ecuación de reacción

ethyl 3-(4-pyrimidinyl)-3-oxopropionate

5,5-dimethyl-4,5-dihydro-1H-imidazol-2-ylamine hydrobromide

potassium carbonate

→

2,2-Dimethyl-7-pyrimidin-4-yl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawere heated
2. 2
   Temperaturaat reflux temperature during 18 h.

Procedimiento

A mixture containing 2.09 (10.3 mmol) of ethyl 3-(4-pyrimidinyl)-3-oxopropionate, 2.0 g (10.3 mmol) of 5,5-dimethyl-4,5-dihydro-1H-imidazol-2-ylamine hydrobromide and 2.85 g (20.6 mmol) of potassium carbonate in 15 ml of methanol were heated at reflux temperature during 18 h.

Fuente